The efficacy and safety of pulsed-field ablation in para-Hisian paroxysmal supraventricular tachycardia: first-in-human pilot trial

Abstract Funding Acknowledgements Type of funding sources: Public Institution(s). Main source(s): National Key Research and Development Program China Background Para-Hisian paroxysmal supraventricular tachycardia (PSVT) is associated with a higher risk atrioventricular block due to proximity the His bundle during catheter ablation. Pulsed-field ablation (PFA) high tissue selectivity may be promising technique for in patients para-Hisian PSVT. Purpose This study aimed evaluate efficacy safety PFA Methods investigator-initiated, single-center, single-arm, prospective was first in-human pilot phase novel system Patients diagnosed PSVT via electrophysiological examination were included treated PFA. The primary outcome ability achieve acute success. secondary success after 3 months. Results A total seven mean age 49.4±13.1 years underwent Acute achieved all patients. skin-to-skin procedure time 135.0±17.7 minutes, fluoroscopy 4.3±1.6 number applications 7±1.6. No adverse events occurred any patient or 3-month follow-up. Conclusion had favorable can help minimize inadvertent treatment choice